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Structure of 22423-26-3
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2,2'-Anhydro-5-methyluridine features a rigidified furanose ring system that enhances conformational stability in nucleoside analogs. This structural constraint improves resistance to enzymatic degradation while maintaining favorable binding affinity for RNA polymerases. The 5-methyl group contributes to enhanced hydrophobic interactions in duplex contexts, making this derivative valuable for probing nucleic acid dynamics and designing stable antisense oligonucleotides.
2,2'-Anhydro-5-methyluridine serves as a valuable building block in nucleoside synthesis, offering a rigidified furanose scaffold that facilitates stereoselective glycosylation reactions. Its anhydro bridge enhances conformational stability and improves resistance to hydrolysis, enabling reliable use in automated oligonucleotide assembly and the construction of modified RNA analogs. The 5-methyl substitution provides enhanced metabolic stability and improved binding affinity in therapeutic applications.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: