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Structure of 22446-37-3
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Methyl 2-(2-hydroxyphenyl)acetate features a phenolic hydroxyl group ortho to a benzyl ester moiety, enabling intramolecular hydrogen bonding that enhances stability and modulates reactivity. This structural motif supports efficient integration into synthetic routes for bioactive heterocycles and functionalized aromatics under standard conditions.
Methyl 2-(2-hydroxyphenyl)acetate serves as a versatile building block in synthetic organic chemistry, enabling efficient access to benzoxazole and benzothiazole scaffolds via cyclization reactions. Its ortho-hydroxyaryl functionality facilitates directed metalation and electrophilic substitution, while the ester group offers compatibility with standard coupling and reduction protocols. Bench-stable and readily purified by column chromatography, it functions reliably in multi-step syntheses of bioactive heterocycles and pharmaceutical intermediates.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: