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Structure of 224584-18-3
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This trifluoromethyl-substituted bicyclic acid features a rigid, sterically constrained [1.1.1]bicyclo[1.1.1]pentane core that imparts exceptional metabolic stability and enhanced membrane permeability. The carboxylic acid group enables direct conjugation or derivatization in medicinal chemistry campaigns. Its electron-withdrawing trifluoromethyl moiety modulates pKa and lipophilicity, offering precise tuning of physicochemical properties for drug discovery applications.
3-(Trifluoromethyl)bicyclo[1.1.1]pentane-1-carboxylic acid serves as a rigid, sterically constrained building block for medicinal chemistry and materials science. Its trifluoromethyl group imparts enhanced lipophilicity and metabolic stability, while the bicyclo[1.1.1]pentane core provides exceptional conformational rigidity and low polar surface area. The carboxylic acid functionality enables direct coupling or derivatization in standard peptide and small-molecule synthesis workflows, facilitating efficient access to bioactive scaffolds with improved pharmacokinetic profiles.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: