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Structure of 2248-46-6
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Ethyl 2,2-difluoro-2-phenylacetate features a sterically congested α-difluoromethyl group flanked by a phenyl ring and ester functionality. This configuration imparts enhanced metabolic stability and electron-withdrawing character, enabling its use in the synthesis of fluorinated pharmaceutical intermediates. The molecule exhibits robust bench stability under standard conditions and facilitates efficient incorporation into complex molecular architectures via nucleophilic substitution or cross-coupling processes.
Ethyl 2,2-difluoro-2-phenylacetate serves as a versatile building block in synthetic organic chemistry, enabling the construction of fluorinated aromatic motifs via standard functional group interconversions. Its difluoromethyl group imparts enhanced metabolic stability and lipophilicity, making it valuable for medicinal chemistry applications. The compound exhibits good bench stability, facilitates straightforward purification, and participates reliably in nucleophilic substitution and elimination reactions within established synthetic workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315-H319-H335
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Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P405-P501
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Lot numbers can be found on the outside label of a product: