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CS-W001157 4
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7-Bromo-2,4-dichloro-6,8-difluoroquinazoline

  • CAS No. 2248318-27-4

  • Cat. No. CS-0415956
  • Molecule weight313.91
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

7-Bromo-2,4-dichloro-6,8-difluoroquinazoline|CS-0415956

Structure of 2248318-27-4

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General Information

  • CAS No. 2248318-27-4
  • Cat. No. CS-0415956
  • Purity ≥95%
  • MDL No. None
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈HBrCl₂F₂N₂
  • Molecular Weight 313.91
  • Synonym(s) None
  • SMILES FC1=C(Br)C(F)=CC2=C(Cl)N=C(Cl)N=C12

Description

7-Bromo-2,4-dichloro-6,8-difluoroquinazoline features a highly electron-deficient quinazoline core functionalized with bromo, chloro, and fluoro substituents at strategic positions. This combination enhances reactivity in cross-coupling processes while maintaining stability under standard conditions. The molecule serves as a key intermediate in the synthesis of advanced pharmaceutical agents and functional materials requiring precise electronic tuning.

Application

7-Bromo-2,4-dichloro-6,8-difluoroquinazoline serves as a versatile building block for the synthesis of biologically active quinazoline derivatives. Its strategically positioned halogen substituents enable sequential cross-coupling reactions, facilitating the construction of complex heterocyclic scaffolds. The molecule exhibits excellent bench stability and compatibility with standard Pd-catalyzed transformations, making it ideal for medicinal chemistry campaigns and API intermediate development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   25.78
  • LogP   3.9773
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

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