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CS-W001157 4
Total: USD 88.00

Boc-NH-PEG3-NHS ester

  • CAS No. 2250216-93-2

  • Cat. No. CS-0115278
  • Purity≥97%
  • MDL No.MFCD31811545
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

Boc-NH-PEG3-NHS ester|CS-0115278

Structure of 2250216-93-2

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Description

Boc-NH-PEG3-NHS ester features a trifunctional linkage: a Boc-protected amine, a three-unit PEG spacer, and a reactive NHS ester. This combination enables site-specific conjugation to primary amines under physiological conditions while maintaining solubility and stability. The PEG3 chain minimizes non-specific binding, enhancing performance in bioconjugation workflows. Ideal for labeling proteins, peptides, or surface-functionalizing nanoparticles with controlled hydrophilicity and reduced aggregation.

Application

Boc-NH-PEG3-NHS ester serves as a versatile bifunctional linker for protein and peptide conjugation, combining the stability of the Boc protecting group with the reactivity of the NHS ester. The PEG3 spacer enhances solubility and reduces steric hindrance, enabling efficient coupling to primary amines under physiological conditions. Ideal for site-specific bioconjugation, it facilitates the synthesis of antibody-drug conjugates and peptide-protein hybrids with improved handling and purification characteristics.

General Information

  • CAS No. 2250216-93-2
  • Cat. No. CS-0115278
  • Purity ≥97%
  • MDL No. MFCD31811545
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₈H₃₀N₂O₉
  • Molecular Weight 418.44
  • Synonym(s) None
  • SMILES O=C(CCOCCOCCOCCNC(OC(C)(C)C)=O)ON(C1=O)C(CC1)=O

Computational Chemistry Data

  • TPSA   129.7
  • LogP   0.5582
  • H_Acceptors   9
  • H_Donors   1
  • Rotatable_Bonds   13

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362

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