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Bis[(trimethylsilyl)methyl](1,5-cyclooctadiene)palladium(II)

  • CAS No. 225931-80-6

  • Cat. No. CS-0084018
  • Purity≥98%
  • MDL No.MFCD16621467

*For research and further manufacturing use only, not for direct human use.

Bis[(trimethylsilyl)methyl](1,5-cyclooctadiene)palladium(II)|CS-0084018

Structure of 225931-80-6

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General Information

  • CAS No. 225931-80-6
  • Cat. No. CS-0084018
  • Purity ≥98%
  • MDL No. MFCD16621467
  • Storage -20°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₆H₃₄PdSi₂
  • Molecular Weight 389.03
  • Synonym(s) (1,5-Cyclooctadiene)bis(triMethylsilylMethyl)palladiuM(II)
  • SMILES C[Si](C)(C)C[Pd]C[Si](C)(C)C.C1/C=C\CC/C=C\C1

Description

Bis[(trimethylsilyl)methyl](1,5-cyclooctadiene)palladium(II) delivers a stable, moisture-tolerant Pd(II) source for cross-coupling reactions. The trimethylsilyl groups enhance solubility and reduce aggregation, while the 1,5-cyclooctadiene ligand facilitates controlled reductive elimination. This complex enables efficient C–C and C–heteroatom bond formation under mild conditions.

Application

Bis[(trimethylsilyl)methyl](1,5-cyclooctadiene)palladium(II) serves as a stable, bench-ready palladium source for cross-coupling reactions, enabling efficient C–C bond formation via oxidative addition. Its trimethylsilylmethyl groups enhance functional group tolerance and facilitate in situ generation of reactive intermediates. The 1,5-cyclooctadiene ligand provides kinetic stability while allowing facile displacement during catalytic cycles, making it well-suited for Suzuki-Miyaura, Negishi, and Stille couplings in medicinal chemistry and process development workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS02,GHS07
Signal Word : Danger
UN#: 1325
Class : 4.1
Packing Group : Ⅲ
Hazard Statements : H228-H315-H319-H335
Precautionary Statements : P210-P240-P241-P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P370+P378-P405-P501

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Computational Chemistry Data

  • TPSA   0
  • LogP   6.3331
  • H_Acceptors   0
  • H_Donors   0
  • Rotatable_Bonds   4

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