(R)-4-Hydroxypyrrolidin-2-one

Name: (R)-4-Hydroxypyrrolidin-2-one
Brand: ChemScene
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CAS No. 22677-21-0
Cat. No. CS-W013709
Purity≥97%
MDL No.MFCD00273364

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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(R)-4-Hydroxypyrrolidin-2-one|CS-W013709

Structure of 22677-21-0

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Description

(R)-4-Hydroxypyrrolidin-2-one is a stereochemically defined heterocyclic scaffold featuring a hydroxyl group at the C4 position and a lactam functionality. This configuration imparts enhanced solubility and metabolic stability, enabling its use in asymmetric synthesis and as a chiral building block for bioactive molecules.

Application

(R)-4-Hydroxypyrrolidin-2-one serves as a versatile chiral building block in medicinal chemistry, enabling efficient access to pyrrolidine-based pharmacophores. Its hydroxyl group provides a handle for selective derivatization, while the lactam functionality offers inherent stability and favorable solubility. The stereochemistry at C4 ensures predictable stereoselective transformations, facilitating its use in asymmetric synthesis and API development.

General Information

CAS No. 22677-21-0
Cat. No. CS-W013709
Purity ≥97%
MDL No. MFCD00273364
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₄H₇NO₂
Molecular Weight 101.10
Synonym(s) (R)-(+)-4-Hydroxy-2-pyrrolidone
SMILES O=C1NC[C@H](O)C1

Computational Chemistry Data

TPSA 49.33
LogP -1.1328
H_Acceptors 2
H_Donors 2
Rotatable_Bonds 0

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

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Other Classifications

Building Blocks Skeleton Aliphatic heterocycle compounds Pyrrolidine compounds

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Key Words

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(R)-4-Hydroxypyrrolidin-2-one

CAS No. 22677-21-0

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