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CS-W001157 4
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Propylene glycol dilaurate

  • CAS No. 22788-19-8

  • Cat. No. CS-0185653
  • Purity≥98%
  • MDL No.MFCD00083068

*For research and further manufacturing use only, not for direct human use.

Propylene glycol dilaurate|CS-0185653

Structure of 22788-19-8

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General Information

  • CAS No. 22788-19-8
  • Cat. No. CS-0185653
  • Purity ≥98%
  • MDL No. MFCD00083068
  • Storage Sealed in dry,2-8℃
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₇H₅₂O₄
  • Molecular Weight 440.70
  • Synonym(s) None
  • SMILES CCCCCCCCCCCC(=O)OCC(C)OC(=O)CCCCCCCCCCC

Description

A cell-permeable indole compound that acts as a potent, ATP-competitive, and isozyme-selective p38 MAP kinase inhibitor (IC50 = 3.2 nM). It inhibits p38 only at much higher concentrations (IC50 = 122 nM) and exhibits little activity against p38, ERK2, JNK-1, or MAPKAPK-2 even at concentrations as high as 50 M. When administered to NOD mice via food intake in vivo, SD-169 is shown to prevent the development of type 1 diabetes in prediabetic mice and display therapeutic efficacy in treating animals already in mild and moderate hyperglycemic states.

Synthesis

  • Route1

    References

    • Omar, Ibrahim Che; Nishio, Naomichi; Nagai, Shiro Agricultural and Biological Chemistry, 1987 , vol. 51, # 8 p. 2153 - 2160
  • Route2

    References

    • Journal of the American Oil Chemists' Society, , vol. 36, p. 34
  • Route3

    References

    • JAOCS, Journal of the American Oil Chemists' Society, , vol. 71, # 7 p. 715 - 719

Safety Information

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GHS Pictogram : N/A
GHS No : N/A
Signal Word : N/A
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : N/A
Precautionary Statements : N/A

Quality Control

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Computational Chemistry Data

  • TPSA   52.6
  • LogP   8.3031
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   23

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