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Structure of 228572-69-8
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This ketone features a trifluoromethyl-substituted phenyl ring linked to an acetyl group, delivering enhanced electron-withdrawing character and improved metabolic stability. The ortho-hydroxyl group enables intramolecular hydrogen bonding, increasing rigidity and influencing reactivity in synthetic transformations. Ideal for constructing complex heterocycles and functionalized scaffolds in medicinal chemistry and materials science applications.
1-(2-Hydroxy-4-trifluoromethyl-phenyl)-ethanone serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles and pharmaceutical intermediates. Its trifluoromethyl group enhances metabolic stability and modulates lipophilicity, while the phenolic hydroxyl and ketone functionalities offer orthogonal handles for derivatization. The compound exhibits good bench stability and facilitates efficient functional group transformations in standard synthetic workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: