2-Bromo-4-chloropyridine

Name: 2-Bromo-4-chloropyridine
Brand: ChemScene
Availability: InStock
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CAS No. 22918-01-0
Cat. No. CS-W003129
Purity≥97%
MDL No.MFCD03840757

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

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Structure of 22918-01-0

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Description

2-Bromo-4-chloropyridine is a halogenated pyridine derivative featuring complementary reactive sites for cross-coupling and functionalization. The bromine at the 2-position enables palladium-catalyzed transformations, while the chlorine at the 4-position offers orthogonal reactivity. This bifunctional architecture supports modular synthesis in medicinal chemistry and materials science.

Application

2-Bromo-4-chloropyridine serves as a versatile building block in heterocyclic synthesis, enabling palladium-catalyzed cross-coupling reactions due to its orthogonal halogen reactivity. The bromo group facilitates efficient Suzuki, Stille, or Negishi coupling, while the chloro substituent offers stability under reaction conditions. This compound exhibits excellent bench stability and is readily purified by distillation or recrystallization, making it ideal for scalable synthesis of pharmaceutical intermediates and functionalized pyridine scaffolds.

General Information

CAS No. 22918-01-0
Cat. No. CS-W003129
Purity ≥97%
MDL No. MFCD03840757
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₃BrClN
Molecular Weight 192.44
Synonym(s) None
SMILES BrC1=CC(Cl)=CC=N1

Computational Chemistry Data

TPSA 12.89
LogP 2.4975
H_Acceptors 1
H_Donors 0
Rotatable_Bonds 0

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS05,GHS07
Signal Word : Danger	UN#: 1759
Class : 8	Packing Group : Ⅲ
Hazard Statements : H302-H315-H318-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Other Classifications

Bioactive Molecules Dye and Bio-assay Reagents

Building Blocks Functional Group Chloride

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

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2-Bromo-4-chloropyridine

CAS No. 22918-01-0

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