Dihydrofuran-3(2H)-one

Name: Dihydrofuran-3(2H)-one
Brand: ChemScene
Availability: InStock
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CAS No. 22929-52-8
Cat. No. CS-D1574
Purity≥98%
MDL No.MFCD07778393

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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General Information

CAS No. 22929-52-8
Cat. No. CS-D1574
Purity ≥98%
MDL No. MFCD07778393
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₄H₆O₂
Molecular Weight 86.09
Synonym(s) 3-Oxotetrahydrofuran
SMILES O=C1COCC1

Description

Dihydrofuran-3(2H)-one features a reactive α,β-unsaturated carbonyl system that enables efficient Michael additions and cycloadditions. This bench-stable heterocycle integrates readily into synthetic sequences requiring electrophilic or enolizable functionality, offering high reactivity with nucleophiles under mild conditions.

Application

Dihydrofuran-3(2H)-one serves as a versatile building block in synthetic organic chemistry, enabling efficient access to substituted furan derivatives and heterocyclic scaffolds. Its inherent electrophilic character at the carbonyl carbon facilitates nucleophilic addition and cycloaddition reactions, while its stability under standard bench conditions supports straightforward handling and purification. Widely employed in medicinal chemistry and natural product synthesis, it functions as a key intermediate for constructing bioactive frameworks with predictable reactivity profiles.

Safety Information

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GHS Pictogram :	GHS No : GHS02,GHS07
Signal Word : Danger	UN#: 1993
Class : 3	Packing Group : Ⅲ
Hazard Statements : H335-H226-H302-H315-H319
Precautionary Statements : P210-P233-P240-P241-P242-P243-P260-P264-P270-P271-P280-P301+P310-P302+P352-P303+P361+P353-P304+P340-P305+P351+P338-P312-P330-P332+P313-P337+P313-P362+P364-P370+P378-P403+P235-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 26.3
LogP -0.0242
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Ketone

Building Blocks Skeleton Aliphatic heterocycle compounds Tetrahydrofuran compounds

Key Words

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Dihydrofuran-3(2H)-one

CAS No. 22929-52-8

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