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CS-W001157 4
Total: USD 88.00

2-(Piperidin-4-yl)propan-2-ol

  • CAS No. 22990-34-7

  • Cat. No. CS-0052213
  • Molecule weight143.23
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-(Piperidin-4-yl)propan-2-ol|CS-0052213

Structure of 22990-34-7

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General Information

  • CAS No. 22990-34-7
  • Cat. No. CS-0052213
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₇NO
  • Molecular Weight 143.23
  • Synonym(s) 4-Piperidinemethanol, alpha,alpha-dimethyl-
  • SMILES CC(C)(O)C1CCNCC1

Description

This piperidinylpropanol derivative features a sterically hindered tertiary alcohol and a basic piperidine ring, enabling efficient incorporation into bioactive scaffolds. The structure combines enhanced solubility with metabolic stability, facilitating use in medicinal chemistry campaigns targeting CNS disorders and kinase inhibitors under standard bench conditions.

Application

2-(Piperidin-4-yl)propan-2-ol serves as a valuable chiral building block in medicinal chemistry, offering a sterically hindered tertiary alcohol adjacent to a saturated nitrogen heterocycle. Its piperidine core provides favorable solubility and metabolic stability, while the benzylic-like tertiary alcohol enables straightforward derivatization via protection or functional group interconversion. The compound exhibits excellent bench stability and compatibility with standard coupling and reduction protocols, facilitating its use in the synthesis of diverse bioactive molecules and API intermediates.

Synthesis

  • Route1
    • null|null
      160809-39-2
    • ~99%
    • In-stock
      2-(Piperidin-4-yl)propan-2-ol|CS-0052213
      22990-34-7

    References

    • Eisai Co., Ltd. Patent: EP1522540 A1, 2005 ; Location in patent: Page/Page column 64 ; EP 1522540 A1
  • Route2

    References

    • Moosa, Basem A.; Ali, Shaikh A. Arkivoc, 2010 , vol. 2010, # 10 p. 132 - 148
  • Route3

    References

    • Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 22 p. 6938 - 6942,5

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   32.26
  • LogP   0.7569
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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