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Structure of 2302-25-2
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4-Bromo-1H-imidazole is a bench-stable heterocyclic reagent featuring a bromine atom at the 4-position of the imidazole ring. This configuration enables direct functionalization in cross-coupling reactions, offering efficient access to substituted imidazoles. The electron-deficient nature of the ring enhances reactivity in palladium-catalyzed transformations.
4-Bromo-1H-imidazole serves as a versatile building block in synthetic organic chemistry, enabling palladium-catalyzed cross-coupling reactions to construct imidazole-based scaffolds. Its bromine substituent provides reliable reactivity in Suzuki, Stille, and Negishi couplings, while the imidazole core offers moderate basicity and hydrogen-bonding capacity. The compound exhibits excellent bench stability and facilitates straightforward purification, making it well-suited for medicinal chemistry campaigns and process-scale synthesis of heterocyclic intermediates.
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GHS Pictogram :
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GHS No : GHS06
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Signal Word : Danger
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UN#: 2811
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Class : 6.1
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Packing Group : Ⅲ
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Hazard Statements : H301-H315-H319-H335
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Precautionary Statements : P264-P270-P330-P405-P501
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Lot numbers can be found on the outside label of a product: