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Structure of 23039-94-3
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Tris(3-fluorophenyl)phosphine delivers enhanced electron density and steric bulk, enabling efficient coupling in palladium-catalyzed cross-coupling reactions. The fluorinated aryl groups improve stability and solubility under standard conditions, while the phosphine core ensures robust coordination to transition metals. This reagent excels in challenging transformations requiring high functional group tolerance and minimal catalyst deactivation.
Tris(3-fluorophenyl)phosphine serves as a robust, bench-stable ligand in palladium-catalyzed cross-coupling reactions. Its electron-withdrawing fluorophenyl groups enhance oxidative stability and improve catalytic efficiency in Suzuki-Miyaura and Negishi couplings. The ligand exhibits excellent functional group tolerance and facilitates reactions under mild conditions, enabling efficient synthesis of biaryl and complex heterocyclic scaffolds common in pharmaceutical development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: