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CS-W001157 4
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Tert-butyl ((2S,4R)-2-methylpiperidin-4-yl)carbamate

  • CAS No. 2305078-76-4

  • Cat. No. CS-0504651
  • Molecule weight214.30
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

Tert-butyl ((2S,4R)-2-methylpiperidin-4-yl)carbamate|CS-0504651

Structure of 2305078-76-4

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General Information

  • CAS No. 2305078-76-4
  • Cat. No. CS-0504651
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₂₂N₂O₂
  • Molecular Weight 214.30
  • Synonym(s) None
  • SMILES O=C(OC(C)(C)C)N[C@H]1C[C@H](C)NCC1

Description

Tert-butyl ((2S,4R)-2-methylpiperidin-4-yl)carbamate is a stereochemically defined building block featuring a chiral piperidine core with a tert-butyl carbamate handle. This protected amine integrates readily into complex molecular architectures, offering stability under standard bench conditions and compatibility with diverse synthetic transformations.

Application

Tert-butyl ((2S,4R)-2-methylpiperidin-4-yl)carbamate serves as a key chiral building block in medicinal chemistry, enabling efficient access to bioactive piperidine scaffolds. The tert-butyl carbamate group provides excellent bench stability and facilitates straightforward deprotection under mild acidic conditions. Its (2S,4R)-configuration supports stereoselective synthesis, while the methyl substituent enhances metabolic stability. This compound functions effectively in coupling reactions, reductive amination protocols, and heterocycle construction for API development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   50.36
  • LogP   1.6516
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   1

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