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Structure of 2338-71-8
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5-Fluoroindole-3-carboxaldehyde features a fluorinated indole core with an aldehyde handle at the 3-position, enabling direct incorporation into heterocyclic scaffolds. The electron-deficient aromatic system enhances reactivity in nucleophilic additions, while the bench-stable aldehyde group facilitates straightforward derivatization under standard conditions.
5-Fluoroindole-3-carboxaldehyde serves as a versatile building block for the synthesis of biologically active heterocycles and pharmaceutical intermediates. Its aldehyde functionality enables efficient imine formation, reductive amination, and Ugi-type multicomponent reactions. The electron-withdrawing fluorine substituent enhances electrophilicity at the C3 position and improves metabolic stability in downstream candidates. Bench-stable and compatible with standard purification methods, it facilitates scalable access to indole-based scaffolds in medicinal chemistry workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315-H319-H335
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Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: