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CS-W001157 4
Total: USD 88.00

1-(3-(Benzyloxy)-4-methoxyphenyl)ethanone

  • CAS No. 23428-77-5

  • Cat. No. CS-0155119
  • Purity≥96%
  • MDL No.MFCD00183289

*For research and further manufacturing use only, not for direct human use.

1-(3-(Benzyloxy)-4-methoxyphenyl)ethanone|CS-0155119

Structure of 23428-77-5

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General Information

  • CAS No. 23428-77-5
  • Cat. No. CS-0155119
  • Purity ≥96%
  • MDL No. MFCD00183289
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₆H₁₆O₃
  • Molecular Weight 256.30
  • Synonym(s) 1-(4-methoxy-3-phenylmethoxyphenyl)ethanone
  • SMILES CC(=O)C1=CC(=C(C=C1)OC)OCC2=CC=CC=C2

Description

1-(3-(Benzyloxy)-4-methoxyphenyl)ethanone features a benzyl ether-linked methoxyaryl ketone scaffold, combining lipophilic aromatic character with polar ether and carbonyl functionalities. This configuration enables robust integration into complex molecular architectures, particularly in medicinal chemistry and natural product synthesis, where stable linkage and controlled reactivity are essential.

Application

1-(3-(Benzyloxy)-4-methoxyphenyl)ethanone serves as a versatile aryl ketone building block for medicinal chemistry and natural product synthesis. Its benzyloxy and methoxy substituents provide orthogonal protection and electronic modulation, enabling selective functionalization. The ketone group facilitates aldol reactions, nucleophilic additions, and reductive transformations under standard conditions. Bench-stable and amenable to purification via crystallization or chromatography, it functions reliably in multi-step syntheses requiring robust intermediates.

Synthesis

  • Route1
    • 3-Hydroxy-4-methoxyacetophenone Diosmin Impurity|CS-0229711
      6100-74-9
    • null|null
      100-39-0
    • ~69%
    • In-stock
      1-(3-(Benzyloxy)-4-methoxyphenyl)ethanone|CS-0155119
      23428-77-5

    References

    • Bose, P.; Banerji, J. Phytochemistry (Elsevier), 1991 , vol. 30, # 7 p. 2438 - 2439
  • Route2
    • null|null
      154490-49-0
    • ~86%
    • In-stock
      1-(3-(Benzyloxy)-4-methoxyphenyl)ethanone|CS-0155119
      23428-77-5

    References

    • Janin; Bisagni Tetrahedron, 1993 , vol. 49, # 45 p. 10305 - 10316
  • Route3
    • In-stock
      Isovanillin|CS-W009023
      621-59-0
    • null|null
      100-44-7
    • ~93%
    • In-stock
      1-(3-(Benzyloxy)-4-methoxyphenyl)ethanone|CS-0155119
      23428-77-5

    References

    • Janin; Bisagni Tetrahedron, 1993 , vol. 49, # 45 p. 10305 - 10316

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS09
Signal Word : Warning
UN#: 3077
Class : 9
Packing Group : Ⅲ
Hazard Statements : H400
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   35.53
  • LogP   3.4768
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   5

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