(R)-3-(tert-Butyl)-4-(2,6-dimethoxy-3,5-dimethylphenyl)-2,3-dihydrobenzo[d][1,3]oxaphosphole

Name: (R)-3-(tert-Butyl)-4-(2,6-dimethoxy-3,5-dimethylphenyl)-2,3-dihydrobenzo[d][1,3]oxaphosphole
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CAS No. 2351219-88-8
Cat. No. CS-0092205
Purity≥97%
MDL No.MFCD32641159

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(R)-3-(tert-Butyl)-4-(2,6-dimethoxy-3,5-dimethylphenyl)-2,3-dihydrobenzo[d][1,3]oxaphosphole|CS-0092205

Structure of 2351219-88-8

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Description

(R)-3-(tert-Butyl)-4-(2,6-dimethoxy-3,5-dimethylphenyl)-2,3-dihydrobenzo[d][1,3]oxaphosphole is a chiral phosphole derivative featuring a sterically shielded tert-butyl group and an electron-rich aryl moiety. This bench-stable compound integrates readily into asymmetric catalysis workflows, where its rigid, three-dimensional architecture enables precise stereocontrol in transition metal-mediated transformations.

Application

(R)-3-(tert-Butyl)-4-(2,6-dimethoxy-3,5-dimethylphenyl)-2,3-dihydrobenzo[d][1,3]oxaphosphole serves as a sterically encumbered, bench-stable phosphole derivative enabling selective P–C bond formation in transition-metal-catalyzed cross-coupling reactions. Its ortho-dimethylated aryl substituent enhances stability and modulates electronic properties, while the chiral oxaphosphole core facilitates stereocontrolled synthesis of phosphorus-containing heterocycles. Functions effectively as a building block in the construction of biologically relevant scaffolds and catalyst precursors.

General Information

CAS No. 2351219-88-8
Cat. No. CS-0092205
Purity ≥97%
MDL No. MFCD32641159
Storage 4°C, protect from light, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₂₁H₂₇O₃P
Molecular Weight 358.41
Synonym(s) (3R)-4-(2,6-Dimethoxy-3,5-dimethylphenyl)-3-(2-methyl-2-propanyl)-2,3-dihydro-1,3-benzoxaphosphole
SMILES COC1=C(C)C=C(C)C(OC)=C1C2=C([P@@](C(C)(C)C)CO3)C3=CC=C2

Computational Chemistry Data

TPSA 27.69
LogP 5.24324
H_Acceptors 3
H_Donors 0
Rotatable_Bonds 3

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

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(R)-3-(tert-Butyl)-4-(2,6-dimethoxy-3,5-dimethylphenyl)-2,3-dihydrobenzo[d][1,3]oxaphosphole

CAS No. 2351219-88-8

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