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Structure of 2353-33-5
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Decitabine is a nucleoside analog that integrates into DNA, where it induces irreversible cytosine methylation inhibition. This mechanism promotes demethylation of silenced tumor suppressor genes, restoring their expression in malignant cells. The compound exhibits potent antineoplastic activity in hematologic malignancies and is stable under standard storage conditions.
Decitabine serves as a clinically validated nucleoside analog used in the treatment of myelodysplastic syndromes and acute myeloid leukemia. It functions as a DNA methyltransferase inhibitor, incorporating into DNA during replication to induce hypomethylation and reactivate silenced genes. Its stability under physiological conditions and predictable metabolic activation make it a reliable tool for epigenetic studies and therapeutic applications in oncology research.
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GHS Pictogram :
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GHS No : GHS07,GHS08
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335-H341-H360
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: