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CS-W001157 4
Total: USD 88.00

Decitabine

  • CAS No. 2353-33-5

  • Cat. No. CS-0372
  • Molecule weight228.21
  • Purity≥98%
  • MDL No.MFCD00043011

*For research and further manufacturing use only, not for direct human use.

Decitabine|CS-0372

Structure of 2353-33-5

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General Information

  • CAS No. 2353-33-5
  • Cat. No. CS-0372
  • Purity ≥98%
  • MDL No. MFCD00043011
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₂N₄O₄
  • Molecular Weight 228.21
  • Synonym(s) 5-Aza-2'-deoxycytidine; 5-AZA-CdR; NSC 127716
  • SMILES O[C@H]1C[C@H](N2C(N=C(N)N=C2)=O)O[C@@H]1CO

Description

Decitabine is a nucleoside analog that integrates into DNA, where it induces irreversible cytosine methylation inhibition. This mechanism promotes demethylation of silenced tumor suppressor genes, restoring their expression in malignant cells. The compound exhibits potent antineoplastic activity in hematologic malignancies and is stable under standard storage conditions.

Application

Decitabine serves as a clinically validated nucleoside analog used in the treatment of myelodysplastic syndromes and acute myeloid leukemia. It functions as a DNA methyltransferase inhibitor, incorporating into DNA during replication to induce hypomethylation and reactivate silenced genes. Its stability under physiological conditions and predictable metabolic activation make it a reliable tool for epigenetic studies and therapeutic applications in oncology research.

Synthesis

  • Route1

    References

    • EP2371825 A1, ; Page/Page column 9 ;
  • Route2

    References

    • EP2048151 A1, ; Page/Page column 3 ;
  • Route3
    • 5-Acetoxy-2-(((4-chlorobenzoyl)oxy)methyl)tetrahydrofuran-3-yl 4-chlorobenzoate|CS-0454126
      1207459-15-1
    • Bis(trimethylsilyl)-5-azacytosine|CS-0032923
      52523-35-0
    • ~%
    • In-stock
      Decitabine|CS-0372
      2353-33-5

    References

    • US2010/36112 A1, ; Page/Page column 7-8 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07,GHS08
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335-H341-H360
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   123.49
  • LogP   -2.1388
  • H_Acceptors   8
  • H_Donors   3
  • Rotatable_Bonds   2

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