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CS-W001157 4
Total: USD 88.00

4-Chloro-3-formylphenylboronic acid

  • CAS No. 2354338-14-8

  • Cat. No. CS-0178452
  • Purity≥97%
  • MDL No.None
  • HazMat Fee +

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    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

4-Chloro-3-formylphenylboronic acid|CS-0178452

Structure of 2354338-14-8

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Description

4-Chloro-3-formylphenylboronic acid features a boronic acid group paired with an ortho-formyl substituent on a chlorinated aromatic ring, enabling efficient coupling in Suzuki-Miyaura reactions. This configuration supports direct functionalization of complex heterocycles and facilitates the synthesis of biaryl scaffolds with enhanced electronic tunability.

Application

4-Chloro-3-formylphenylboronic acid serves as a versatile building block in Suzuki-Miyaura coupling reactions, enabling efficient C–C bond formation under mild conditions. The orthogonal reactivity of the aldehyde and boronic acid groups facilitates sequential functionalization, while its bench-stable nature simplifies handling and purification. This compound is particularly valuable for constructing complex aromatic scaffolds in medicinal chemistry and materials science.

General Information

  • CAS No. 2354338-14-8
  • Cat. No. CS-0178452
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆BClO₃
  • Molecular Weight 184.38
  • Synonym(s) None
  • SMILES OB(C1=CC=C(Cl)C(C=O)=C1)O

Computational Chemistry Data

  • TPSA   57.53
  • LogP   -0.1677
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   2

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362+P364

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