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CS-W001157 4
Total: USD 88.00

3-Hydroxy-1-(4-methoxybenzyl)piperidine-2,6-dione

  • CAS No. 2357109-89-6

  • Cat. No. CS-0610961
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

3-Hydroxy-1-(4-methoxybenzyl)piperidine-2,6-dione|CS-0610961

Structure of 2357109-89-6

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General Information

  • CAS No. 2357109-89-6
  • Cat. No. CS-0610961
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₁₅NO₄
  • Molecular Weight 249.26
  • Synonym(s) 3-hydroxy-1-[(4-methoxyphenyl)methyl]piperidine-2.6-dione
  • SMILES O=C(C(O)CC1)N(CC2=CC=C(OC)C=C2)C1=O

Description

This piperidinedione scaffold integrates a 4-methoxybenzyl group and a hydroxyl substituent, offering enhanced solubility and stability under standard bench conditions. The para-methoxyaryl moiety provides electron-donating character, while the hydroxy function enables downstream derivatization. This structure serves as a key intermediate in the synthesis of bioactive alkaloids and pharmaceutical candidates.

Application

3-Hydroxy-1-(4-methoxybenzyl)piperidine-2,6-dione serves as a versatile building block for heterocyclic synthesis, enabling efficient access to piperidine-based scaffolds via reductive cyclization or functional group manipulation. Its bench-stable nature, combined with orthogonal protection and tolerance to standard reaction conditions, facilitates streamlined workflows in medicinal chemistry and process development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   66.84
  • LogP   0.7051
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   3

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