3-Hydroxy-1-(4-methoxybenzyl)piperidine-2,6-dione

Name: 3-Hydroxy-1-(4-methoxybenzyl)piperidine-2,6-dione
Brand: ChemScene
Availability: InStock
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CAS No. 2357109-89-6
Cat. No. CS-0610961
Purity≥97%
MDL No.None

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3-Hydroxy-1-(4-methoxybenzyl)piperidine-2,6-dione|CS-0610961

Structure of 2357109-89-6

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Description

This piperidinedione scaffold integrates a 4-methoxybenzyl group and a hydroxyl substituent, offering enhanced solubility and stability under standard bench conditions. The para-methoxyaryl moiety provides electron-donating character, while the hydroxy function enables downstream derivatization. This structure serves as a key intermediate in the synthesis of bioactive alkaloids and pharmaceutical candidates.

Application

3-Hydroxy-1-(4-methoxybenzyl)piperidine-2,6-dione serves as a versatile building block for heterocyclic synthesis, enabling efficient access to piperidine-based scaffolds via reductive cyclization or functional group manipulation. Its bench-stable nature, combined with orthogonal protection and tolerance to standard reaction conditions, facilitates streamlined workflows in medicinal chemistry and process development.

General Information

CAS No. 2357109-89-6
Cat. No. CS-0610961
Purity ≥97%
MDL No. None
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₃H₁₅NO₄
Molecular Weight 249.26
Synonym(s) 3-hydroxy-1-[(4-methoxyphenyl)methyl]piperidine-2.6-dione
SMILES O=C(C(O)CC1)N(CC2=CC=C(OC)C=C2)C1=O

Computational Chemistry Data

TPSA 66.84
LogP 0.7051
H_Acceptors 4
H_Donors 1
Rotatable_Bonds 3

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Other Classifications

Building Blocks Skeleton Aliphatic heterocycle compounds Piperidine compounds

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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3-Hydroxy-1-(4-methoxybenzyl)piperidine-2,6-dione

CAS No. 2357109-89-6

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