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CS-W001157 4
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α-Demethylnaproxen

  • CAS No. 23981-47-7

  • Cat. No. CS-0127451
  • Molecule weight216.24
  • Purity≥98%
  • MDL No.MFCD00033105

*For research and further manufacturing use only, not for direct human use.

α-Demethylnaproxen|CS-0127451

Structure of 23981-47-7

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General Information

  • CAS No. 23981-47-7
  • Cat. No. CS-0127451
  • Purity ≥98%
  • MDL No. MFCD00033105
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₁₂O₃
  • Molecular Weight 216.24
  • Synonym(s) 2-(6-Methoxynaphthalen-2-yl)acetic acid
  • SMILES O=C(O)CC1=CC=C2C=C(OC)C=CC2=C1

Description

Phosphatidylcholine(PC) is one of the most important constituent of colons mucosal layer. 14:0-18:0 PC (1-myristoyl-2-stearoyl-sn-glycero-3-phosphocholine) is an asymmetrical lipid with long alkyl side chain.14:0-18:0 PC (1-myristoyl-2-stearoyl-sn-glycero-3-phosphocholine) may be used:in lipid bilayers to study its miscibility with d-erythro-N-palmitoyl-sphingomyelin (16:0-SM) using differential scanning calorimetry (DSC)as an asymmetricallipid component in liposomes to study the impact of bilayer area and lipid geometry and as liposomal solubilizing agentsto prepare a low temperature-sensitive liposome for thrombolytic studies

Application

α-Demethylnaproxen serves as a key intermediate in the synthesis of naproxen and related NSAIDs, enabling efficient access to the core 2-arylpropionic acid scaffold. Its functional group tolerance and bench stability facilitate straightforward derivatization and chiral resolution. The compound functions reliably in standard coupling and oxidation protocols, supporting scalable production workflows for pharmaceutical R&D.

Synthesis

  • Route1
    • null|null
      53077-21-7
    • ~90%
    • In-stock
      α-Demethylnaproxen|CS-0127451
      23981-47-7

    References

    • Tetrahedron Letters, , vol. 50, # 31 p. 4541 - 4544
  • Route2
    • null|null
      54828-56-7
    • ~91%
    • In-stock
      α-Demethylnaproxen|CS-0127451
      23981-47-7

    References

    • ACS Medicinal Chemistry Letters, , vol. 3, # 9 p. 759 - 763
  • Route3
    • 2-(6-Methoxynaphthalen-2-yl)acetonitrile|CS-0303041
      71056-96-7
    • ~98%
    • In-stock
      α-Demethylnaproxen|CS-0127451
      23981-47-7

    References

    • Chemical Communications, , vol. 46, # 10 p. 1697 - 1699

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P260-P264-P270-P271-P280-P301+P310-P302+P352-P304+P340-P305+P351+P338-P312-P330-P332+P313-P337+P313-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   46.53
  • LogP   2.4755
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   3

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