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CS-W001157 4
Total: USD 88.00

4,5-Dibromophthalic acid

  • CAS No. 24063-28-3

  • Cat. No. CS-0157857
  • Purity≥98%
  • MDL No.MFCD00623825

*For research and further manufacturing use only, not for direct human use.

4,5-Dibromophthalic acid|CS-0157857

Structure of 24063-28-3

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General Information

  • CAS No. 24063-28-3
  • Cat. No. CS-0157857
  • Purity ≥98%
  • MDL No. MFCD00623825
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₄Br₂O₄
  • Molecular Weight 323.92
  • Synonym(s) None
  • SMILES O=C(O)C1=CC(Br)=C(Br)C=C1C(=O)O

Description

4,5-Dibromophthalic acid features two bromine substituents at adjacent positions on the phthalic core, delivering enhanced electrophilicity and facilitating selective cross-coupling reactions. This dibrominated aromatic diacid serves as a key building block in synthesizing functionalized polymers and bioactive molecules under standard conditions.

Application

4,5-Dibromophthalic acid serves as a versatile building block in synthetic organic chemistry, enabling the construction of brominated aromatic scaffolds via palladium-catalyzed cross-coupling reactions. Its orthogonal reactivity profile facilitates sequential functionalization, while the carboxylic acid groups allow for derivatization or salt formation to improve solubility and purification. Bench-stable and readily available, it functions as a key intermediate in the synthesis of heterocyclic systems and functionalized phthalimides.

Synthesis

  • Route1

    References

    • Gould, Ken J.; Hacker, Nigel P.; McOmie, John F. W.; Perry, David H. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 1834 - 1840
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      4,5-Dibromophthalic acid|CS-0157857
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    References

    • Juvalta Patent: DE50117 ; Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 2, p. 94
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      4,5-Dibromophthalic acid|CS-0157857
      24063-28-3

    References

    • Bluemlein Chemische Berichte, 1884 , vol. 17, p. 2494

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   74.6
  • LogP   2.608
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   2

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