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CS-W001157 4
Total: USD 88.00

4-Methoxy-2-methylpyridine

  • CAS No. 24103-75-1

  • Cat. No. CS-W005919
  • Purity≥98%
  • MDL No.MFCD06253892

*For research and further manufacturing use only, not for direct human use.

4-Methoxy-2-methylpyridine|CS-W005919

Structure of 24103-75-1

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General Information

  • CAS No. 24103-75-1
  • Cat. No. CS-W005919
  • Purity ≥98%
  • MDL No. MFCD06253892
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₉NO
  • Molecular Weight 123.15
  • Synonym(s) None
  • SMILES COC1=CC(C)=NC=C1

Description

4-Methoxy-2-methylpyridine is a bench-stable, electron-rich heterocycle featuring a para-methoxy group and a sterically accessible methyl substituent. This combination enhances its utility in transition metal-catalyzed cross-coupling reactions and as a ligand scaffold in coordination chemistry.

Application

4-Methoxy-2-methylpyridine serves as a versatile heterocyclic building block in medicinal chemistry and catalysis. Its ortho-methyl and para-methoxy substituents enable directed metallation and facilitate cross-coupling reactions. The compound exhibits good bench stability, moderate polarity, and compatibility with common protecting group strategies, making it well-suited for iterative synthesis of complex pharmaceutical scaffolds and functionalized pyridine derivatives.

Synthesis

  • Route1
    • null|null
      5470-66-6
    • ~0%
    • In-stock
      4-Amino-2-methylpyridine|CS-D0974
      18437-58-6
    • In-stock
      4-Methoxy-2-methylpyridine|CS-W005919
      24103-75-1
    • null|null
      14045-17-1
    • null|null
      100421-65-6

    References

    • Ovchinnikov, V. G.; Litvinenko, G. S.; Maksimenko, N. M.; Sherstyuk, A. I.; Levkov, V. A. J. Appl. Chem. USSR (Engl. Transl.), 1989 , vol. 62, # 7.2 p. 1577 - 1586,1460 - 1468
  • Route2
    • In-stock
      2-Chloro-4-methoxypyridine|CS-W007914
      17228-69-2
    • null|null
      5158-46-3
    • ~51%
    • In-stock
      4-Methoxy-2-methylpyridine|CS-W005919
      24103-75-1

    References

    • Tung, Yen-Shih; Coumar, Mohane Selvaraj; Wu, Yu-Shan; Shiao, Hui-Yi; Chang, Jang-Yang; Liou, Jing-Ping; Shukla, Paritosh; Chang, Chun-Wei; Chang, Chi-Yen; Kuo, Ching-Chuan; Yeh, Teng-Kuang; Lin, Chin-Yu; Wu, Jian-Sung; Wu, Su-Ying; Liao, Chun-Chen; Hsieh, Hsing-Pang Journal of Medicinal Chemistry, 2011 , vol. 54, # 8 p. 3076 - 3080
  • Route3
    • null|null
      6890-60-4
    • ~78%
    • In-stock
      4-Methoxy-2-methylpyridine|CS-W005919
      24103-75-1

    References

    • Olah, George A.; Arvanaghi, Massoud; Vankar, Yashwant D. Synthesis, 1980 , # 8 p. 660 - 661

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   22.12
  • LogP   1.39862
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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