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CS-W001157 4
Total: USD 88.00

(2S,4S)-4-Fluoropyrrolidine-2-carboxylic acid

  • CAS No. 2438-57-5

  • Cat. No. CS-0058726
  • Purity≥97%
  • MDL No.MFCD02683983

*For research and further manufacturing use only, not for direct human use.

(2S,4S)-4-Fluoropyrrolidine-2-carboxylic acid|CS-0058726

Structure of 2438-57-5

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General Information

  • CAS No. 2438-57-5
  • Cat. No. CS-0058726
  • Purity ≥97%
  • MDL No. MFCD02683983
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₈FNO₂
  • Molecular Weight 133.12
  • Synonym(s) H-(2S,4S)-PRO(4-F)-OH
  • SMILES F[C@H]1C[C@@H](C(O)=O)NC1

Description

(2S,4S)-4-Fluoropyrrolidine-2-carboxylic acid is a conformationally constrained, fluorinated proline analog featuring a rigid pyrrolidine ring with defined stereochemistry. This configuration imparts enhanced metabolic stability and precise spatial orientation, making it ideal for incorporating into peptidomimetics and bioactive small molecules where controlled backbone geometry is critical.

Synthesis

  • Route1
    • null|null
      156046-04-7
    • ~56%
    • In-stock
      (2S,4S)-4-Fluoropyrrolidine-2-carboxylic acid|CS-0058726
      2438-57-5

    References

    • Burger, Klaus; Rudolph, Martin; Fehn, Susanna; Sewald, Norbert Journal of Fluorine Chemistry, 1994 , vol. 66, # 1 p. 87 - 90
  • Route2
    • null|null
      148429-59-8
    • ~%
    • In-stock
      (2S,4S)-4-Fluoropyrrolidine-2-carboxylic acid|CS-0058726
      2438-57-5

    References

    • Journal of Labelled Compounds and Radiopharmaceuticals, , vol. 42, # 12 p. 1135 - 1144
  • Route3

    References

    • Tetrahedron Letters, , vol. 39, # 10 p. 1169 - 1172

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H320-H335
Precautionary Statements : P261-P280-P302+P352

Quality Control

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Computational Chemistry Data

  • TPSA   49.33
  • LogP   -0.229
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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