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N-Succinyl-L-phenylalanine-p-nitroanilide

  • CAS No. 2440-62-2

  • Cat. No. CS-0142506
  • Purity≥98%
  • MDL No.MFCD00047721

*For research and further manufacturing use only, not for direct human use.

N-Succinyl-L-phenylalanine-p-nitroanilide|CS-0142506

Structure of 2440-62-2

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General Information

  • CAS No. 2440-62-2
  • Cat. No. CS-0142506
  • Purity ≥98%
  • MDL No. MFCD00047721
  • Storage Sealed in dry,2-8℃
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₉H₁₉N₃O₆
  • Molecular Weight 385.37
  • Synonym(s) N-SUCCINYL-L-PHENYLALANINE P-NITROANILIDE
  • SMILES O=C(NC(C=C1)=CC=C1[N](=O)=O)[C@@H](NC(CCC(O)=O)=O)CC2=CC=CC=C2

Description

N-Succinyl-L-phenylalanine-p-nitroanilide (CAS 2440-62-2) is hydrolyzed by chymotrypsin at the amide bond, releasing p-nitroaniline as a chromogenic indicator in enzymatic activity assays.

Application

N-Succinyl-L-phenylalanine-p-nitroanilide (CAS 2440-62-2) drives chymotrypsin hydrolysis studies by serving as a chromogenic substrate that releases p-nitroaniline upon cleavage. This enables real-time activity monitoring. Researchers leverage its high molar absorptivity to quantify enzyme kinetics and assess α-chymotrypsin inhibition in vitro with precision.

Synthesis

  • Route1

    References

    • Okada; Tsuda; Teno; Nagamatsu; Okamoto Chemical and Pharmaceutical Bulletin, 1988 , vol. 36, # 12 p. 4794 - 4801
  • Route2
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      14235-15-5
    • ~%
    • N-Succinyl-L-phenylalanine-p-nitroanilide|CS-0142506
      2440-62-2

    References

    • Matsuo, Takashi; Imai, Chie; Yoshida, Takefumi; Saito, Takashi; Hayashi, Takashi; Hirota, Shun Chemical Communications, 2012 , vol. 48, # 11 p. 1662 - 1664
  • Route3

    References

    • Matsuo, Takashi; Imai, Chie; Yoshida, Takefumi; Saito, Takashi; Hayashi, Takashi; Hirota, Shun Chemical Communications, 2012 , vol. 48, # 11 p. 1662 - 1664

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   138.64
  • LogP   2.1256
  • H_Acceptors   5
  • H_Donors   3
  • Rotatable_Bonds   9

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