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CS-W001157 4
Total: USD 88.00

4-Hydroxy-5-methoxy-2-nitrobenzaldehyde

  • CAS No. 2454-72-0

  • Cat. No. CS-0030147
  • Purity≥98%
  • MDL No.MFCD00034536
  • HazMat Fee +

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    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

4-Hydroxy-5-methoxy-2-nitrobenzaldehyde|CS-0030147

Structure of 2454-72-0

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Description

4-Hydroxy-5-methoxy-2-nitrobenzaldehyde features a nitro group at the para position relative to the aldehyde, enhancing electrophilicity for nucleophilic additions. The phenolic hydroxyl and methoxy substituents provide polar functionality, improving solubility in protic solvents. This compound serves as a key intermediate in the synthesis of bioactive heterocycles and fluorescent probes due to its electron-deficient aromatic core and orthogonal functional handles.

Application

4-Hydroxy-5-methoxy-2-nitrobenzaldehyde serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling efficient access to substituted benzimidazoles, quinoline derivatives, and other heterocyclic scaffolds. Its ortho-dihydroxy and nitro-aldehyde functionalities provide orthogonal reactivity for sequential transformations, while the methoxy group enhances solubility and modulates electronic properties. Bench-stable and readily purified by recrystallization, it facilitates reliable use in multi-step syntheses.

General Information

  • CAS No. 2454-72-0
  • Cat. No. CS-0030147
  • Purity ≥98%
  • MDL No. MFCD00034536
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₇NO₅
  • Molecular Weight 197.14
  • Synonym(s) 6-Nitrovanillin; Entacapone Impurity 68
  • SMILES O=CC1=CC(OC)=C(O)C=C1[N+]([O-])=O

Computational Chemistry Data

  • TPSA   89.67
  • LogP   1.1215
  • H_Acceptors   5
  • H_Donors   1
  • Rotatable_Bonds   3

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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