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Structure of 24621-73-6
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4-Chloro-1H-indole-2-carboxylic acid features a chlorine-substituted indole core with a carboxylic acid group at the 2-position, offering enhanced electron-withdrawing character and improved solubility in polar solvents. This scaffold integrates readily into bioactive molecule design, particularly in medicinal chemistry applications involving heterocyclic scaffolds.
4-Chloro-1H-indole-2-carboxylic acid serves as a versatile building block in medicinal chemistry, enabling direct incorporation into indole-based scaffolds via standard coupling reactions. Its carboxylic acid functionality facilitates amide, ester, and hydrazide formation under mild conditions, while the 4-chloro substituent provides a handle for palladium-catalyzed cross-coupling or nucleophilic aromatic substitution. The compound exhibits good bench stability and is readily purified by recrystallization, supporting efficient integration into multi-step syntheses of bioactive molecules.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: