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CS-W001157 4
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4-methyl-2,3-dihydro-1H-inden-1-one

  • CAS No. 24644-78-8

  • Cat. No. CS-W004334
  • Purity≥97%
  • MDL No.MFCD00015759

*For research and further manufacturing use only, not for direct human use.

4-methyl-2,3-dihydro-1H-inden-1-one|CS-W004334

Structure of 24644-78-8

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General Information

  • CAS No. 24644-78-8
  • Cat. No. CS-W004334
  • Purity ≥97%
  • MDL No. MFCD00015759
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₀O
  • Molecular Weight 146.19
  • Synonym(s) 4-methyl-2,3-dihydroinden-1-one
  • SMILES O=C1CCc2c1cccc2C

Description

4-Methyl-2,3-dihydro-1H-inden-1-one features a rigid, fused bicyclic core with a ketone functionality at the bridgehead position. This electron-deficient carbonyl group enables efficient conjugate addition reactions and serves as a key scaffold in synthetic intermediates for pharmaceuticals and functional materials. The methyl substituent enhances solubility and steric profile, improving handling under standard bench conditions.

Application

4-Methyl-2,3-dihydro-1H-inden-1-one serves as a versatile building block in synthetic organic chemistry, enabling efficient access to substituted indane and indole scaffolds. Its conjugated enone system facilitates Michael additions, electrophilic substitutions, and transition-metal-catalyzed coupling reactions. The molecule exhibits good bench stability and is readily purified by crystallization or column chromatography, making it well-suited for iterative synthesis workflows in medicinal chemistry and process development.

Synthesis

  • Route1

    References

    • MERIAL LIMITED; MENG, Charles, Q. Patent: WO2013/74892 A1, 2013 ; Location in patent: Page/Page column 39-40 ;
  • Route2
    • null|null
      201230-82-2
    • null|null
      3989-15-9
    • ~62%
    • In-stock
      4-methyl-2,3-dihydro-1H-inden-1-one|CS-W004334
      24644-78-8

    References

    • Takeuchi, Ryo; Yasue, Hiroyuki Journal of Organic Chemistry, 1993 , vol. 58, # 20 p. 5386 - 5392
  • Route3

    References

    • Chorghade, Rajeev; Battilocchio, Claudio; Hawkins, Joel M.; Ley, Steven V. Organic Letters, 2013 , vol. 15, # 22 p. 5698 - 5701

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   17.07
  • LogP   2.12392
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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