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CS-W001157 4
Total: USD 88.00

H-N-Me-Ser-OH

  • CAS No. 2480-26-4

  • Cat. No. CS-W013588
  • Purity≥97%
  • MDL No.MFCD00037756

*For research and further manufacturing use only, not for direct human use.

H-N-Me-Ser-OH|CS-W013588

Structure of 2480-26-4

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General Information

  • CAS No. 2480-26-4
  • Cat. No. CS-W013588
  • Purity ≥97%
  • MDL No. MFCD00037756
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₉NO₃
  • Molecular Weight 119.12
  • Synonym(s) None
  • SMILES OC[C@@H](C(O)=O)NC

Description

H-N-Me-Ser-OH is a synthetically accessible, bench-stable amino acid derivative featuring a methylated serine side chain. This N-terminal protected variant integrates readily into peptide synthesis workflows, offering enhanced solubility and reduced epimerization risk during coupling steps.

Application

H-N-Me-Ser-OH serves as a valuable building block for peptide synthesis, offering a methylated serine residue with enhanced metabolic stability. The N-methyl group improves resistance to proteolytic degradation while maintaining compatibility with standard coupling protocols. Its hydroxyl functionality enables selective derivatization for peptidomimetic and macrocyclic scaffold construction, making it well-suited for medicinal chemistry applications requiring improved bioavailability and structural diversity.

Synthesis

  • Route1
    • null|null
      173947-21-2
    • ~64%
    • In-stock
      H-N-Me-Ser-OH|CS-W013588
      2480-26-4

    References

    • Aurelio, Luigi; Brownlee, Robert T. C.; Hughes, Andrew B.; Sleebs, Brad E. Australian Journal of Chemistry, 2000 , vol. 53, # 5 p. 425 - 433
  • Route2
    • null|null
      50-00-0
    • In-stock
      2-(Benzylamino)-3-hydroxypropanoic acid|CS-0437387
      106910-76-3
    • ~%
    • In-stock
      H-N-Me-Ser-OH|CS-W013588
      2480-26-4

    References

    • Helvetica Chimica Acta, , vol. 46, p. 327 - 333

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H319
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   69.56
  • LogP   -1.3487
  • H_Acceptors   3
  • H_Donors   3
  • Rotatable_Bonds   3

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