Lot numbers can be found on the outside label of a product:
Methyl 2-nitroacetate
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CAS No. 2483-57-0
- Cat. No. CS-0130670
- Purity≥97%
- MDL No.MFCD00075480
*For research and further manufacturing use only, not for direct human use.
Structure of 2483-57-0
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General Information
- CAS No. 2483-57-0
- Cat. No. CS-0130670
- Purity ≥97%
- MDL No. MFCD00075480
- Storage 4°C
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₃H₅NO₄
- Molecular Weight 119.08
- Synonym(s) Nitroacetic Acid Methyl Ester
- SMILES O=C(OC)C[N+]([O-])=O
Description
Methyl nitroacetate may be used:in the preparation of aromatic and heteroaromatic linear (E)--nitro-arylpentenoatesto generate phenyliodonium ylide, used in the highly enantioselective and diastereoselective Cu(I)-catalyzed cyclopropanation of alkenesin the preparation of methyl (Z)-2-nitro-3-(4-nitrophenyl)-2-propenoate, via reaction with 4-nitrobenzylideneaniline
Application
Methyl 2-nitroacetate serves as a versatile building block in synthetic organic chemistry, enabling efficient construction of nitro-containing heterocycles and α-functionalized carboxylates. Its electrophilic α-carbon facilitates nucleophilic additions and condensations, particularly in the synthesis of pyrroles, isoxazoles, and β-nitro carbonyl compounds. The molecule exhibits good bench stability, mild handling requirements, and compatibility with diverse reaction conditions, making it a practical choice for multi-step syntheses and medicinal chemistry applications.
Synthesis
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Route1
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108-05-4 -
10102-43-9
- ~63%
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In-stock
2483-57-0
References
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UBE Industries, Ltd. Patent: US4433162 A1, 1984 ;
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Route2
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108-05-4
- ~53%
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In-stock
2483-57-0
References
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UBE Industries, Ltd. Patent: US4433162 A1, 1984 ;
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Route3
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67-56-1
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625-75-2
- ~78%
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In-stock
2483-57-0
References
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Mori, Hisakazu; Okubo, Mutsuko; Oke, Yoshiko; Noguchi, Nobuko; Fukuda, Miho; Ishihara, Masao Chemical & Pharmaceutical Bulletin, 1984 , vol. 32, # 6 p. 2200 - 2204
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315-H319-H335
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Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 69.44
- LogP -0.5639
- H_Acceptors 4
- H_Donors 0
- Rotatable_Bonds 2
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