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Structure of 2483-57-0
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Methyl nitroacetate may be used:in the preparation of aromatic and heteroaromatic linear (E)--nitro-arylpentenoatesto generate phenyliodonium ylide, used in the highly enantioselective and diastereoselective Cu(I)-catalyzed cyclopropanation of alkenesin the preparation of methyl (Z)-2-nitro-3-(4-nitrophenyl)-2-propenoate, via reaction with 4-nitrobenzylideneaniline
Methyl 2-nitroacetate serves as a versatile building block in synthetic organic chemistry, enabling efficient construction of nitro-containing heterocycles and α-functionalized carboxylates. Its electrophilic α-carbon facilitates nucleophilic additions and condensations, particularly in the synthesis of pyrroles, isoxazoles, and β-nitro carbonyl compounds. The molecule exhibits good bench stability, mild handling requirements, and compatibility with diverse reaction conditions, making it a practical choice for multi-step syntheses and medicinal chemistry applications.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315-H319-H335
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Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: