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CS-W001157 4
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1,5-Dimethylpyrazole-3-carbaldehyde

  • CAS No. 25016-10-8

  • Cat. No. CS-0061282
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

1,5-Dimethylpyrazole-3-carbaldehyde|CS-0061282

Structure of 25016-10-8

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General Information

  • CAS No. 25016-10-8
  • Cat. No. CS-0061282
  • Purity ≥98%
  • MDL No. None
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₈N₂O
  • Molecular Weight 124.14
  • Synonym(s) 1,5-dimethyl-1H-pyrazole-3-carbaldehyde
  • SMILES CC1=CC(=NN1C)C=O

Description

1,5-Dimethylpyrazole-3-carbaldehyde features a pyrazole core functionalized with methyl groups at positions 1 and 5, delivering enhanced solubility and steric protection. The aldehyde group at C3 enables direct coupling in multistep syntheses, particularly useful in medicinal chemistry for constructing heterocyclic scaffolds. This compound demonstrates stability under standard bench conditions and serves as a key intermediate in the development of bioactive molecules.

Application

1,5-Dimethylpyrazole-3-carbaldehyde serves as a versatile building block in medicinal chemistry and heterocyclic synthesis, enabling efficient access to pyrazole-based scaffolds. Its aldehyde functionality facilitates reductive amination, condensation reactions, and transition-metal-catalyzed couplings. The methyl groups at the 1- and 5-positions enhance stability and solubility, while the electron-rich pyrazole ring supports diverse functionalization. This compound functions effectively in both small-molecule discovery and process development workflows.

Synthesis

  • Route1
    • null|null
      124237-07-6
    • ~78%
    • In-stock
      1,5-Dimethylpyrazole-3-carbaldehyde|CS-0061282
      25016-10-8

    References

    • Journal of Heterocyclic Chemistry, , vol. 26, p. 893 - 898
  • Route2
    • 1,1-Diethoxypentane-2,4-dione|CS-0299197
      124237-06-5
    • ~%
    • In-stock
      1,5-Dimethylpyrazole-3-carbaldehyde|CS-0061282
      25016-10-8

    References

    • Journal of Heterocyclic Chemistry, , vol. 26, p. 893 - 898

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   34.89
  • LogP   0.54102
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

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