2'-O-MOE-rC

Name: 2'-O-MOE-rC
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 251647-54-8
Cat. No. CS-0608886
Purity≥95%
MDL No.None

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HazMat Fee

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Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

Structure of 251647-54-8

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Description

2'-O-MOE-rC combines a 2'-O-methoxyethyl modification with a ribocytidine scaffold, delivering enhanced nuclease resistance and improved binding affinity. This modified nucleoside integrates seamlessly into antisense oligonucleotides, enabling stable duplex formation under physiological conditions.

Application

2'-O-MOE-rC serves as a robust nucleoside building block for antisense oligonucleotide synthesis, offering enhanced nuclease resistance and improved binding affinity due to the 2'-O-methoxyethyl modification. Its stability under physiological conditions facilitates reliable incorporation into therapeutic sequences, while its compatibility with standard phosphoramidite chemistry enables efficient solid-phase synthesis and straightforward purification.

General Information

CAS No. 251647-54-8
Cat. No. CS-0608886
Purity ≥95%
MDL No. None
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₄₉H₅₈N₅O₁₀P
Molecular Weight 907.99
Synonym(s) None
SMILES COC(C=C1)=CC=C1C(C2=CC=CC=C2)(C3=CC=C(OC)C=C3)OC[C@@H]4[C@@H](OP(N(C(C)C)C(C)C)OCCC#N)[C@@H](OCCOC)[C@H](N5C(N=C(NC(C6=CC=CC=C6)=O)C=C5)=O)O4

Computational Chemistry Data

TPSA 164.86
LogP 8.11168
H_Acceptors 14
H_Donors 1
Rotatable_Bonds 23

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

Quality Control

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Other Classifications

Life Science Nucleosides & Nucleotides Nucleosides, Deoxyribonucleosides and Other Nucleosides

Chemical Biology Pharmaceutical Development and Drug Discovery Research Nucleic Acid Chemistry Nucleoside Phosphoramidites

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Nucleic Acid Chemistry Nucleoside Phosphoramidites

Biochemistry Biochemicals and Reagents Nucleosides, Nucleotides, Oligonucleotides Nucleobases and their Analogs

Biochemistry Biochemicals and Reagents Nucleosides, Nucleotides, Oligonucleotides Nucleoside Analogs

Biochemistry Biochemicals and Reagents Nucleosides, Nucleotides, Oligonucleotides Nucleosides

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2'-O-MOE-rC

CAS No. 251647-54-8

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