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CS-W001157 4
Total: USD 88.00

3-(3,4,5-Trimethoxyphenyl)propanoic acid

  • CAS No. 25173-72-2

  • Cat. No. CS-0041622
  • Molecule weight240.25
  • Purity≥98%
  • MDL No.MFCD00002775

*For research and further manufacturing use only, not for direct human use.

3-(3,4,5-Trimethoxyphenyl)propanoic acid|CS-0041622

Structure of 25173-72-2

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General Information

  • CAS No. 25173-72-2
  • Cat. No. CS-0041622
  • Purity ≥98%
  • MDL No. MFCD00002775
  • Storage 4°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₁₆O₅
  • Molecular Weight 240.25
  • Synonym(s) 3,4,5-Trimethoxyhydrocinnamic Acid;3-(3,4,5-Trimethoxyphenyl)Propionic Acid
  • SMILES O=C(O)CCC1=CC(OC)=C(OC)C(OC)=C1

Description

This 3-(3,4,5-trimethoxyphenyl)propanoic acid features a highly electron-rich aromatic core flanked by a flexible propanoic acid chain. The three methoxy groups enhance solubility and stability under standard conditions. This structure enables efficient coupling in synthetic workflows, particularly useful in medicinal chemistry for constructing bioactive scaffolds with improved metabolic resistance.

Application

3-(3,4,5-Trimethoxyphenyl)propanoic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive compounds through established coupling and functionalization protocols. Its aromatic core with three methoxy groups enhances solubility and metabolic stability, while the carboxylic acid functionality facilitates direct derivatization via amide, ester, or acyl transfer reactions. The compound exhibits excellent bench stability and is compatible with standard purification methods, making it ideal for high-throughput screening campaigns and API intermediate development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   64.99
  • LogP   1.7296
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   6

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