(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)pentanoic acid

Name: (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)pentanoic acid
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CAS No. 252049-05-1
Cat. No. CS-0089871
Purity≥98%
MDL No.MFCD01861326

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(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)pentanoic acid|CS-0089871

Structure of 252049-05-1

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Description

This chiral fluorenylmethoxycarbonyl-protected amino acid derivative features a bench-stable, moisture-tolerant side chain ideal for solid-phase peptide synthesis. The (S)-configuration ensures stereochemical fidelity during coupling steps, while the fluoren-9-ylmethoxycarbonyl group enables efficient deprotection under mild basic conditions.

Application

(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)pentanoic acid serves as a robust chiral building block for peptide synthesis, enabling efficient Nα-protection with orthogonal deprotection under mild conditions. Its fluorenylmethoxycarbonyl (Fmoc) group ensures high stability during storage and handling, while the methylamino functionality provides a well-defined side chain for downstream derivatization. The molecule exhibits excellent solubility in common organic solvents and facilitates clean coupling reactions, making it ideal for solid-phase and solution-phase peptide assembly workflows.

General Information

CAS No. 252049-05-1
Cat. No. CS-0089871
Purity ≥98%
MDL No. MFCD01861326
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₂₁H₂₃NO₄
Molecular Weight 353.41
Synonym(s) N-Fmoc-N-methyl-L-norvaline
SMILES CCC[C@@H](C(O)=O)N(C(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)=O)C

Computational Chemistry Data

TPSA 66.84
LogP 4.1206
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 6

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Life Science Amino Acids and their Derivatives Valine and derivatives

Life Science Amino Acids and their Derivatives N-protected amino acid

Chemical Biology Pharmaceutical Development and Drug Discovery Research Peptide Chemistry Amino Acid Derivatives

Chemical Biology Pharmaceutical Development and Drug Discovery Research Peptide Chemistry Unnatural Amino Acid Derivatives

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Peptide Chemistry Unnatural Amino Acid Derivatives

Chemical Biology Peptide Chemistry Amine Protection

Chemical Biology Peptide Chemistry Unnatural Amino Acid Derivatives

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(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)pentanoic acid

CAS No. 252049-05-1

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