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CS-W001157 4
Total: USD 88.00

5-Hydroxyisoindolin-1-one

  • CAS No. 252061-66-8

  • Cat. No. CS-W006098
  • Purity≥96%
  • MDL No.MFCD10000830

*For research and further manufacturing use only, not for direct human use.

5-Hydroxyisoindolin-1-one|CS-W006098

Structure of 252061-66-8

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General Information

  • CAS No. 252061-66-8
  • Cat. No. CS-W006098
  • Purity ≥96%
  • MDL No. MFCD10000830
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₇NO₂
  • Molecular Weight None
  • Synonym(s) 5-Hydroxy-2,3-dihydroisoindol-1-one
  • SMILES OC1=CC=C2C(CNC2=O)=C1

Description

5-Hydroxyisoindolin-1-one offers a rigid, electron-rich scaffold ideal for constructing bioactive heterocycles. The hydroxyl group enables direct functionalization or hydrogen bonding interactions, while the lactam carbonyl provides polarity and structural stability under standard conditions. This compound serves as a key intermediate in medicinal chemistry campaigns targeting CNS modulators and kinase inhibitors.

Application

5-Hydroxyisoindolin-1-one serves as a versatile scaffold for medicinal chemistry and synthetic organic applications, enabling efficient access to bioactive heterocycles. The hydroxyl group provides a site for derivatization via esterification or ether formation, while the lactam functionality offers hydrogen bonding capacity and structural rigidity. Bench-stable and compatible with standard functional group manipulations, it facilitates diverse transformations in peptide-like molecule synthesis and drug discovery workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   49.33
  • LogP   0.6356
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   0

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