Lot numbers can be found on the outside label of a product:
Ethyl 2-picolinate
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CAS No. 2524-52-9
- Cat. No. CS-W008053
- Purity≥97%
- MDL No.MFCD00006292
*For research and further manufacturing use only, not for direct human use.
Structure of 2524-52-9
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General Information
- CAS No. 2524-52-9
- Cat. No. CS-W008053
- Purity ≥97%
- MDL No. MFCD00006292
- Storage Store at room temperature
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₈H₉NO₂
- Molecular Weight 151.16
- Synonym(s) Pyridine-2-carboxylic Acid Ethyl Ester
- SMILES C1=C(C(OCC)=O)N=CC=C1
Description
Ethyl 2-picolinate is a bench-stable, moisture-tolerant ester featuring a pyridine ring with a strategically positioned ester group. This configuration enables direct incorporation into heterocyclic synthesis and facilitates transition metal-catalyzed coupling reactions. The electron-deficient pyridine ring enhances reactivity in nucleophilic substitution processes, while the ethyl ester moiety offers improved solubility in common organic solvents.
Application
Ethyl 2-picolinate serves as a versatile building block in synthetic organic chemistry, enabling efficient access to pyridine-based heterocycles and pharmaceutical intermediates. Its ester functionality facilitates nucleophilic acyl substitution and subsequent transformations, while the picolinate core provides a rigid, electron-deficient scaffold compatible with cross-coupling reactions. Bench-stable and readily purified by distillation or chromatography, it functions reliably in multistep syntheses requiring functional group tolerance and predictable reactivity.
Synthesis
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Route1
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109-04-6 -
109-94-4
- ~71%
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In-stock
2524-52-9
References
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Ushijima, Sousuke; Moriyama, Katsuhiko; Togo, Hideo Tetrahedron, 2012 , vol. 68, # 24 p. 4701 - 4709
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Route2
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In-stock
1121-60-4 -
64-17-5
- ~42%
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In-stock
2524-52-9
References
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Chiarotto, Isabella; Feroci, Marta; Sotgiu, Giovanni; Inesi, Achille Tetrahedron, 2013 , vol. 69, # 37 p. 8088 - 8095
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Route3
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In-stock
100-70-9 -
64-17-5
- ~68%
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In-stock
2524-52-9
References
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Luo, Fen-Tair; Jeevanandam, Arumugasamy Tetrahedron Letters, 1998 , vol. 39, # 51 p. 9455 - 9456
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Safety Information
Download SDS|
GHS Pictogram :
N/A
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GHS No : N/A
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Signal Word : N/A
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : N/A
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Precautionary Statements : N/A
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Quality Control
Computational Chemistry Data
- TPSA 39.19
- LogP 1.2583
- H_Acceptors 3
- H_Donors 0
- Rotatable_Bonds 2
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