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Structure of 252771-08-7
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5-Ethynyl-2-hydroxybenzaldehyde features a conjugated alkyne tethered to a phenolic aldehyde, enabling efficient copper-catalyzed azide-alkyne cycloaddition. The hydroxyl group enhances solubility and directs regiochemistry in coupling reactions. This bifunctional scaffold supports modular synthesis of bioactive heterocycles and functionalized aromatic systems under mild conditions.
5-Ethynyl-2-hydroxybenzaldehyde serves as a versatile building block for copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions, enabling efficient access to triazole-linked scaffolds. The molecule combines an aldehyde functionality with a terminal alkyne and phenolic hydroxyl group, offering orthogonal reactivity for sequential conjugations. Its bench-stable nature and compatibility with standard protecting group strategies facilitate integration into multi-step synthetic sequences, particularly in the construction of functionalized heterocycles and bioactive compound libraries.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P260-P264-P270-P271-P280-P301+P310-P302+P352-P304+P340-P305+P351+P338-P312-P330-P332+P313-P337+P313-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: