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CS-W001157 4
Total: USD 88.00

7-Chloroindolin-2-one

  • CAS No. 25369-33-9

  • Cat. No. CS-W008306
  • Purity≥97%
  • MDL No.MFCD06656001

*For research and further manufacturing use only, not for direct human use.

7-Chloroindolin-2-one|CS-W008306

Structure of 25369-33-9

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General Information

  • CAS No. 25369-33-9
  • Cat. No. CS-W008306
  • Purity ≥97%
  • MDL No. MFCD06656001
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₆ClNO
  • Molecular Weight 167.59
  • Synonym(s) 7-Chlorooxindole
  • SMILES O=C1NC2=C(C=CC=C2Cl)C1

Description

7-Chloroindolin-2-one is a bench-stable heterocyclic scaffold featuring a chlorinated indolinone core, offering enhanced electron-withdrawing character and improved solubility in polar organic solvents. This structural motif serves as a key building block in medicinal chemistry, enabling efficient incorporation into kinase inhibitors and bioactive molecules through direct functionalization at the C3 position.

Application

7-Chloroindolin-2-one serves as a versatile building block in medicinal chemistry, enabling efficient access to indole-based scaffolds through standard functional group transformations. Its bench-stable nature and compatibility with diverse coupling reactions facilitate straightforward incorporation into complex molecules. The chloro substituent enhances electrophilic reactivity at the C7 position, supporting further derivatization in key synthetic sequences. This compound functions effectively in the construction of kinase inhibitors and other bioactive heterocycles.

Synthesis

  • Route1
    • null|null
      77158-65-7
    • ~61%
    • In-stock
      7-Chloroindolin-2-one|CS-W008306
      25369-33-9

    References

    • RajanBabu, T. V.; Chenard, Bertrand L.; Petti, Michael A. Journal of Organic Chemistry, 1986 , vol. 51, # 10 p. 1704 - 1712
  • Route2
    • 2-(3-Chloro-2-nitrophenyl)acetic acid|CS-0313039
      23066-21-9
    • ~70%
    • In-stock
      7-Chloroindolin-2-one|CS-W008306
      25369-33-9

    References

    • Dinesh, Bhima Reddy; Baba, A. Ramesha; Sankar, K. Udaya; Gowda, D. Channe Journal of Chemical Research, 2008 , # 5 p. 287 - 288
  • Route3
    • null|null
      77158-65-7
    • ~23%
    • In-stock
      7-Chloroindolin-2-one|CS-W008306
      25369-33-9
    • null|null
      101349-37-5

    References

    • Journal of Organic Chemistry, , vol. 51, # 10 p. 1704 - 1712

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H412
Precautionary Statements : P264-P270-P273-P330-P501

Quality Control

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Computational Chemistry Data

  • TPSA   29.1
  • LogP   1.8346
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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