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CS-W001157 4
Total: USD 88.00

Diethyl (cyanomethyl)phosphonate

  • CAS No. 2537-48-6

  • Cat. No. CS-W018504
  • Molecule weight177.14
  • Purity≥98%
  • MDL No.MFCD00001893

*For research and further manufacturing use only, not for direct human use.

Diethyl (cyanomethyl)phosphonate|CS-W018504

Structure of 2537-48-6

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General Information

  • CAS No. 2537-48-6
  • Cat. No. CS-W018504
  • Purity ≥98%
  • MDL No. MFCD00001893
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₂NO₃P
  • Molecular Weight 177.14
  • Synonym(s) None
  • SMILES N#CCP(OCC)(OCC)=O

Description

Diethyl (cyanomethyl)phosphonate features a cyanomethyl group directly bonded to phosphorus, enabling direct incorporation into phosphorylated building blocks. This moiety delivers enhanced reactivity in nucleophilic substitution and transition-metal-catalyzed coupling reactions. The compound exhibits robust stability under standard conditions and facilitates efficient synthesis of bioactive phosphonates and kinase inhibitors.

Synthesis

  • Route1
    • null|null
      107-14-2
    • null|null
      122-52-1
    • ~10%
    • In-stock
      Diethyl (cyanomethyl)phosphonate|CS-W018504
      2537-48-6

    References

    • BASF AKTIENGESELLSCHAFT Patent: WO2005/63780 A1, 2005 ; Location in patent: Page/Page column 13 ;
  • Route2
    • null|null
      814-49-3
    • null|null
      75-05-8
    • ~86%
    • In-stock
      Diethyl (cyanomethyl)phosphonate|CS-W018504
      2537-48-6

    References

    • Lorga, Bogdan; Ricard, Louis; Savignac, Philippe Journal of the Chemical Society, Perkin Transactions 1, 2000 , # 19 p. 3311 - 3316
  • Route3
    • null|null
      107-14-2
    • null|null
      122-52-1
    • ~85%
    • null|null
      75-00-3
    • In-stock
      Diethyl (cyanomethyl)phosphonate|CS-W018504
      2537-48-6

    References

    • Stache; Fritsch; Fehlhaber Arzneimittel-Forschung/Drug Research, 1987 , vol. 37, # 11 p. 1217 - 1221

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 3278
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H315-H319-H335-H301+H311+H331
Precautionary Statements : P280-P302+P352-P332+P313-P337+P313-P261-P301+P312

Quality Control

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Computational Chemistry Data

  • TPSA   59.32
  • LogP   1.77608
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   5

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