4-Chloro-3-fluoropyridine

Name: 4-Chloro-3-fluoropyridine
Brand: ChemScene
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CAS No. 2546-56-7
Cat. No. CS-W001515
Purity≥97%
MDL No.MFCD03453233

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

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Structure of 2546-56-7

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Description

4-Chloro-3-fluoropyridine features a dual halogen substitution pattern that enables selective cross-coupling and functionalization in pharmaceutical synthesis. The electron-deficient pyridine core pairs with orthogonal reactivity of chlorine and fluorine, facilitating sequential derivatization under mild conditions. This bench-stable heterocycle integrates readily into complex molecular architectures.

Application

4-Chloro-3-fluoropyridine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its orthogonal halogen reactivity. The fluorine and chlorine substituents provide distinct electronic modulation and site-specific functionalization potential. Its bench-stable nature and compatibility with standard reaction conditions facilitate efficient synthesis of pyridine-based pharmaceutical intermediates and heterocyclic scaffolds.

General Information

CAS No. 2546-56-7
Cat. No. CS-W001515
Purity ≥97%
MDL No. MFCD03453233
Storage 4°C, sealed storage, away from moisture
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₃ClFN
Molecular Weight 131.54
Synonym(s) Pyridine, 4-chloro-3-fluoro-
SMILES ClC1=CC=NC=C1F

Computational Chemistry Data

TPSA 12.89
LogP 1.8741
H_Acceptors 1
H_Donors 0
Rotatable_Bonds 0

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS02
Signal Word : Danger	UN#: 1993
Class : 3	Packing Group : Ⅲ
Hazard Statements : H226-H315-H319-H335
Precautionary Statements : P210-P233-P240-P241-P242-P243-P280-P303+P361+P353-P370+P378-P403+P235-P501

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Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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4-Chloro-3-fluoropyridine

CAS No. 2546-56-7

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