2-Chloro-6-methylpyridine-4-carbonitrile

Name: 2-Chloro-6-methylpyridine-4-carbonitrile
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CAS No. 25462-98-0
Cat. No. CS-0051931
Purity≥97%
MDL No.MFCD16658610

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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2-Chloro-6-methylpyridine-4-carbonitrile|CS-0051931

Structure of 25462-98-0

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Description

2-Chloro-6-methylpyridine-4-carbonitrile features a pyridine core functionalized with chlorine, methyl, and nitrile groups at strategic positions, enabling selective coupling in heterocyclic synthesis. The electron-deficient ring facilitates nucleophilic substitution, while the nitrile group serves as a handle for downstream transformations. This compound demonstrates stability under standard bench conditions and compatibility with diverse reaction media.

Application

2-Chloro-6-methylpyridine-4-carbonitrile serves as a versatile building block in synthetic organic chemistry, enabling efficient construction of nitrogen-containing heterocycles and functionalized pharmaceutical scaffolds. Its orthogonal reactivity—combining a chloropyridine electrophile with a nitrile group—facilitates palladium-catalyzed couplings and regioselective transformations under mild conditions. The compound exhibits excellent bench stability and is readily purified by recrystallization or column chromatography, making it well-suited for scalable synthesis and medicinal chemistry applications.

General Information

CAS No. 25462-98-0
Cat. No. CS-0051931
Purity ≥97%
MDL No. MFCD16658610
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₅ClN₂
Molecular Weight None
Synonym(s) 2-Chloro-6-methyl-isonicotinonitrile
SMILES CC1=NC(Cl)=CC(=C1)C#N

Computational Chemistry Data

TPSA 36.68
LogP 1.9151
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 0

Safety Information

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Signal Word : N/A	UN#: N/A
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Hazard Statements : N/A
Precautionary Statements : N/A

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Other Classifications

Building Blocks Functional Group Cyanide/Nitrile

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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2-Chloro-6-methylpyridine-4-carbonitrile

CAS No. 25462-98-0

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