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CS-W001157 4
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1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carbonitrile

  • CAS No. 256376-65-5

  • Cat. No. CS-M2179
  • Purity≥97%
  • MDL No.MFCD20268231

*For research and further manufacturing use only, not for direct human use.

1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carbonitrile|CS-M2179

Structure of 256376-65-5

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General Information

  • CAS No. 256376-65-5
  • Cat. No. CS-M2179
  • Purity ≥97%
  • MDL No. MFCD20268231
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₄H₉FN₄
  • Molecular Weight 252.25
  • Synonym(s) Riociguat-21
  • SMILES FC1=CC=CC=C1CN2C3=NC=CC=C3C(C#N)=N2

Synthesis

  • Route1
    • 1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboxamide|CS-0536368
      256376-62-2
    • ~99%
    • In-stock
      1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carbonitrile|CS-M2179
      256376-65-5

    References

    • BAYER HEALTHCARE AG Patent: WO2004/9589 A1, 2004 ; Location in patent: Page/Page column 30 ;
  • Route2
    • null|null
      407-25-0
    • 1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboxamide|CS-0536368
      256376-62-2
    • ~98%
    • In-stock
      1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carbonitrile|CS-M2179
      256376-65-5

    References

    • Bayer HealthCare AG Patent: US6833364 B1, 2004 ; Location in patent: Page column 33 ;
  • Route3
    • null|null
      446-48-0
    • In-stock
      1H-Pyrazolo[3,4-b]pyridine-3-carbonitrile|CS-W007001
      956010-88-1
    • ~83%
    • In-stock
      1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carbonitrile|CS-M2179
      256376-65-5

    References

    • Griebenow, Nils; Schirok, Hartmut; Mittendorf, Joachim; Straub, Alexander; Follmann, Markus; Stasch, Johannes-Peter; Knorr, Andreas; Schlemmer, Karl-Heinz; Redlich, Gorden Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 5 p. 1197 - 1200

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P261-P280-P304+P340

Quality Control

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Computational Chemistry Data

  • TPSA   54.5
  • LogP   2.49038
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   2

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