4-CHLORO-7-FLUORO-6-METHOXYQUINOLINE

Name: 4-CHLORO-7-FLUORO-6-METHOXYQUINOLINE
Brand: ChemScene
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CAS No. 25759-94-8
Cat. No. CS-0060746
Purity≥98%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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4-CHLORO-7-FLUORO-6-METHOXYQUINOLINE|CS-0060746

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General Information

CAS No. 25759-94-8
Cat. No. CS-0060746
Purity ≥98%
MDL No. None
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₀H₇ClFNO
Molecular Weight 211.62
Synonym(s) None
SMILES C12=CC(=C(C=C1C(=CC=N2)Cl)OC)F

Description

4-Chloro-7-fluoro-6-methoxyquinoline is a fluorinated quinoline derivative featuring strategically positioned halogen and methoxy substituents that enhance electronic modulation and metabolic stability. This electron-deficient scaffold enables direct incorporation into bioactive molecules, particularly in kinase inhibitors and fluorescent probes. The combination of chlorine, fluorine, and methoxy groups provides tunable solubility and reactivity under standard coupling conditions, facilitating efficient synthetic access to complex heterocyclic architectures.

Application

4-Chloro-7-fluoro-6-methoxyquinoline serves as a versatile building block in medicinal chemistry, enabling efficient diversification via palladium-catalyzed cross-coupling reactions. Its electron-deficient quinoline core and orthogonal functional groups—chloro, fluoro, and methoxy—facilitate selective transformations under mild conditions. The compound exhibits excellent bench stability and is compatible with common protecting group strategies, making it ideal for the synthesis of kinase inhibitors and other bioactive heterocycles.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

TPSA 22.12
LogP 3.0359
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds quinoline compounds

Key Words

4-CHLORO-7-FLUORO-6-METHOXYQUINOLINE sigma4-CHLORO-7-FLUORO-6-METHOXYQUINOLINE manufacturer4-CHLORO-7-FLUORO-6-METHOXYQUINOLINE price4-CHLORO-7-FLUORO-6-METHOXYQUINOLINE structure4-CHLORO-7-FLUORO-6-METHOXYQUINOLINE SDSbuy 4-CHLORO-7-FLUORO-6-METHOXYQUINOLINE4-CHLORO-7-FLUORO-6-METHOXYQUINOLINE supplier4-CHLORO-7-FLUORO-6-METHOXYQUINOLINE uses4-CHLORO-7-FLUORO-6-METHOXYQUINOLINE molecular weightprice of 4-CHLORO-7-FLUORO-6-METHOXYQUINOLINE4-CHLORO-7-FLUORO-6-METHOXYQUINOLINE chemical name formula of 4-CHLORO-7-FLUORO-6-METHOXYQUINOLINE

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4-CHLORO-7-FLUORO-6-METHOXYQUINOLINE

CAS No. 25759-94-8

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