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CS-W001157 4
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Iodomethyl isopropyl carbonate

  • CAS No. 258841-42-8

  • Cat. No. CS-0070034
  • Purity≥96%
  • MDL No.MFCD17676831

*For research and further manufacturing use only, not for direct human use.

Iodomethyl isopropyl carbonate|CS-0070034

Structure of 258841-42-8

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General Information

  • CAS No. 258841-42-8
  • Cat. No. CS-0070034
  • Purity ≥96%
  • MDL No. MFCD17676831
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₉IO₃
  • Molecular Weight 244.03
  • Synonym(s) iodomethyl propan-2-yl carbonate
  • SMILES O=C(OC(C)C)OCI

Description

Iodomethyl isopropyl carbonate delivers a reactive iodomethyl group tethered to a stable carbonate ester, enabling efficient alkylation under mild conditions. This bench-stable reagent facilitates selective functionalization in synthetic and medicinal chemistry workflows, particularly in the installation of methylating units with minimal side reactions.

Application

Iodomethyl isopropyl carbonate serves as a versatile alkylating agent in synthetic organic chemistry, enabling efficient introduction of iodomethyl groups under mild conditions. Its stability under ambient storage and compatibility with diverse functional groups make it ideal for selective C-alkylation reactions. The molecule functions as a bench-stable source of electrophilic iodomethyl equivalents, facilitating rapid access to key intermediates in medicinal chemistry and heterocycle synthesis.

Synthesis

  • Route1

    References

    • Thomas, Joshua D.; Sloan, Kenneth B. Tetrahedron Letters, 2007 , vol. 48, # 1 p. 109 - 112

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 1760
Class : 8
Packing Group : Ⅲ
Hazard Statements : H227-H315-H318-H335
Precautionary Statements : P210-P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P370+P378-P403-P405-P501

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Computational Chemistry Data

  • TPSA   35.53
  • LogP   1.9405
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   2

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