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CS-W001157 4
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3-Chloro-2-fluorophenol

  • CAS No. 2613-22-1

  • Cat. No. CS-W018221
  • Molecule weight146.55
  • Purity≥98%
  • MDL No.MFCD01631572

*For research and further manufacturing use only, not for direct human use.

3-Chloro-2-fluorophenol|CS-W018221

Structure of 2613-22-1

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General Information

  • CAS No. 2613-22-1
  • Cat. No. CS-W018221
  • Purity ≥98%
  • MDL No. MFCD01631572
  • Storage RT, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₄ClFO
  • Molecular Weight 146.55
  • Synonym(s) Phenol, 3-chloro-2-fluoro-
  • SMILES OC1=CC=CC(Cl)=C1F

Description

3-Chloro-2-fluorophenol features a fluorine atom ortho to a hydroxyl group and a chlorine substituent at the adjacent position, creating a highly functionalized aromatic scaffold. This electron-deficient phenol integrates readily into synthetic sequences requiring directed ortho-metalation or coupling reactions. The molecule exhibits enhanced stability under standard bench conditions and delivers precise regiochemical control in complex heterocycle assembly.

Application

3-Chloro-2-fluorophenol serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the ortho and meta positions relative to the phenolic hydroxyl group. Its halogenated aromatic framework supports palladium-catalyzed cross-coupling reactions and facilitates electrophilic substitution under controlled conditions. The compound exhibits good bench stability and is amenable to purification via standard techniques, making it well-suited for use in API intermediate synthesis and heterocyclic ring construction.

Synthesis

  • Route1
    • 3-Chloro-2-fluoroaniline Gefitinib Impurity|CS-0167148
      2106-04-9
    • ~%
    • In-stock
      3-Chloro-2-fluorophenol|CS-W018221
      2613-22-1

    References

    • Finger et al. Journal of the American Chemical Society, 1959 , vol. 81, p. 94,95, 97
  • Route2
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      3209-22-1
    • ~%
    • In-stock
      3-Chloro-2-fluorophenol|CS-W018221
      2613-22-1

    References

    • Finger et al. Journal of the American Chemical Society, 1959 , vol. 81, p. 94,95, 97
  • Route3

    References

    • Finger et al. Journal of the American Chemical Society, 1959 , vol. 81, p. 94,95, 97

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H412
Precautionary Statements : P264-P270-P273-P501

Quality Control

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Computational Chemistry Data

  • TPSA   20.23
  • LogP   2.1847
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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